"Vesicle targeting, to, from or within Golgi"

Across TCGA cell cohorts, RNA activity of the "Vesicle targeting, to, from or within Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDXK, MICALL2, and PIWIL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Vesicle targeting, to, from or within Golgi" activity versus PDXK in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDXK →	+0.669	+0.162	.001	<.001	3	4
SKIN	MICALL2 →	+1.405	+0.192	.005	.002	3	4
OVARY	PIWIL4 →	+0.892	+0.342	<.001	.009	3	3
OVARY	DYNC1LI1 →	-0.843	-0.263	<.001	<.001	3	3
OVARY	NOP16 →	-0.831	-0.262	.001	.009	2	4
STOMACH	RRP8 →	-0.851	-0.225	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048199 vs PDXK — LUNG_SCLC

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