Golgi vesicle budding

Across TCGA patient cohorts, RNA activity of the Golgi vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP42, USP34, and ZFC3H1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi vesicle budding activity versus USP42 in KIRP (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	USP42 →	+0.867	+0.071	<.001	<.001	3	34
THYM	USP34 →	+1.746	+0.105	<.001	<.001	3	34
UVM	ZFC3H1 →	+1.117	+0.043	<.001	<.001	3	34
THYM	ROCK2 →	+1.266	+0.105	<.001	<.001	3	34
THYM	DYNC1LI2 →	+1.922	+0.104	<.001	<.001	3	34
UVM	CEP350 →	+1.165	+0.043	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048194 vs USP42 — KIRP

Explore this scatter interactively →