Golgi vesicle budding

Across TCGA patient cohorts, RNA activity of the Golgi vesicle budding pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, LMOD1, and SORBS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi vesicle budding activity versus CLIC2 in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIC2 →	+0.350	+0.043	.006	.005	2	7
CCRCC	LMOD1 →	+0.723	+0.041	<.001	<.001	3	5
CCRCC	SORBS1 →	+0.489	+0.041	.001	<.001	3	5
CCRCC	PPAT →	-0.189	-0.038	.002	.001	3	5
HNSC	ANK2_S890 →	+0.831	+0.100	<.001	<.001	3	5
OV	SMYD3 →	-0.401	-0.039	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048194 vs CLIC2 — LSCC

Explore this scatter interactively →