Golgi vesicle budding

Across TCGA patient cohorts, RNA activity of the Golgi vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS7, KIF14, and PARPBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi vesicle budding activity versus PUS7 in HNSC (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PUS7 →	-0.945	-0.267	<.001	<.001	3	6
LSCC	KIF14 →	-0.757	-0.295	<.001	<.001	3	5
LSCC	PARPBP →	-0.744	-0.321	<.001	<.001	3	5
GBM	PTCHD3P2 →	-0.680	-0.132	<.001	.007	3	5
LSCC	XPO5 →	-0.803	-0.382	<.001	<.001	3	5
UCEC	FBXO46 →	-0.489	-0.261	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048194 vs PUS7 — HNSC

Explore this scatter interactively →