Golgi vesicle budding

Across TCGA cell cohorts, RNA activity of the Golgi vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC86, POLR1E, and DDX21, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi vesicle budding activity versus CCDC86 in BREAST (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCDC86 →	-0.870	-0.138	<.001	.008	3	5
BREAST	POLR1E →	-0.830	-0.141	.007	.006	3	5
BREAST	DDX21 →	-0.688	-0.178	<.001	<.001	3	5
BLOOD_Lymphoma	GTPBP4 →	-0.877	-0.142	<.001	<.001	2	6
BLOOD_Lymphoma	RRP1B →	-0.645	-0.111	<.001	.002	3	5
LARGE_INTESTINE	MAK16 →	-0.806	-0.342	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048194 vs CCDC86 — BREAST

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