Golgi vesicle transport

Across TCGA patient cohorts, RNA activity of the Golgi vesicle transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, YME1L1, and RPL10A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi vesicle transport activity versus RPL5 in BRCA (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.276	-0.040	<.001	<.001	3	9
BRCA	YME1L1 →	-0.415	-0.035	<.001	<.001	3	8
GBM	RPL10A →	-0.221	-0.037	.001	.002	3	7
LSCC	CLPX →	-0.232	-0.023	.007	.004	3	7
BRCA	DDX21 →	-0.639	-0.037	<.001	<.001	3	7
BRCA	MAP1A →	+0.562	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048193 vs RPL5 — BRCA

Explore this scatter interactively →