Golgi vesicle transport

Across TCGA cell cohorts, RNA activity of the Golgi vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREB3L1, IL13RA1, and RPL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi vesicle transport activity versus CREB3L1 in CNS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CREB3L1 →	+2.844	+0.132	<.001	.003	3	6
LIVER	IL13RA1 →	+1.682	+0.245	.001	.001	3	6
SKIN	RPL4 →	-0.455	-0.097	<.001	.005	3	5
LUNG_NSCLC_LUAD	SLC39A7 →	+0.869	+0.166	.002	<.001	3	5
URINARY_TRACT	WDCP →	-0.660	-0.166	.001	.009	2	6
URINARY_TRACT	SLC12A8 →	+2.343	+0.126	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048193 vs CREB3L1 — CNS

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