Regulation of short-term neuronal synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of short-term neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the LGG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3A, PPFIA3, and LUM, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of short-term neuronal synaptic plasticity activity versus RAB3A in LGG (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RAB3A →	+1.782	+0.092	<.001	<.001	3	28
SCLC	PPFIA3 →	+1.249	+0.188	<.001	<.001	3	26
SARC	LUM →	-1.853	-0.031	.001	<.001	2	23
UCS	MOXD1 →	-1.298	-0.059	.007	.001	3	22
LGG	CD86 →	-1.039	-0.076	<.001	<.001	3	21
TGCT	PRRX1 →	-1.235	-0.055	.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048172 vs RAB3A — LGG

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