Regulation of short-term neuronal synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of short-term neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANTXR2, COL8A1, and SYNGR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of short-term neuronal synaptic plasticity activity versus ANTXR2 in HNSC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANTXR2 →	-0.478	-0.273	.006	.005	3	5
GBM	COL8A1 →	-1.879	-0.708	<.001	.001	3	4
GBM	SYNGR1 →	+0.892	+0.799	<.001	<.001	3	4
GBM	OPRD1 →	+0.884	+0.609	<.001	.005	3	4
GBM	LTBP2 →	-0.659	-0.395	.002	.007	3	4
GBM	SUMF1 →	-0.179	-0.638	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048172 vs ANTXR2 — HNSC

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