Regulation of short-term neuronal synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Regulation of short-term neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS3, ACADS, and ACBD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHRS3 grouped by Regulation of short-term neuronal synaptic plasticity-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DHRS3 →	+1.580	+1.409	.009	<.001	3	4
KIDNEY	ACADS →	+1.148	+1.242	.002	<.001	3	3
SOFT_TISSUE	ACBD7 →	-1.787	-1.467	.002	<.001	3	3
LUNG_SCLC	TVP23A →	-0.366	-0.844	.005	.007	3	3
BLOOD_Myeloma	SNRPD3 →	+0.856	+1.765	.001	<.001	3	3
BLOOD_Myeloma	TXN2 →	+0.742	+1.120	.007	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHRS3 by Regulation of short-term neuronal synaptic plasticity activity — UPPER_AERODIGESTIVE_TRACT

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