Positive regulation of long-term neuronal synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Positive regulation of long-term neuronal synaptic plasticity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, NES_S768, and SNRK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of long-term neuronal synaptic plasticity activity versus STXBP1 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP1 →	+0.660	+0.105	<.001	<.001	3	6
BRCA	NES_S768 →	+0.709	+0.087	<.001	<.001	3	6
BRCA	SNRK →	+0.297	+0.065	<.001	<.001	3	5
GBM	REEP4_S152 →	-0.313	-0.090	.001	.003	3	5
CCRCC	SHANK3 →	+0.399	+0.078	<.001	.003	3	5
CCRCC	SNRK_S362 →	+0.568	+0.089	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048170 vs STXBP1 — GBM

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