Positive regulation of long-term neuronal synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Positive regulation of long-term neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMYM3, PLOD2, and NCOR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of long-term neuronal synaptic plasticity activity versus ZMYM3 in LARGE_INTESTINE (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZMYM3 →	+0.746	+0.892	.003	.001	3	5
BREAST	PLOD2 →	+1.806	+0.167	.006	.006	3	5
LARGE_INTESTINE	NCOR2 →	+0.815	+0.764	<.001	<.001	3	5
LARGE_INTESTINE	ASPM →	+0.738	+0.880	.005	.001	3	5
SKIN	MECP2 →	+0.834	+0.180	.001	.004	3	5
LARGE_INTESTINE	DSE →	+0.950	+0.867	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048170 vs ZMYM3 — LARGE_INTESTINE

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