Regulation of long-term neuronal synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of long-term neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMTNL2, TAMALIN, and EMCN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term neuronal synaptic plasticity activity versus SMTNL2 in LSCC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMTNL2 →	+0.456	+0.580	.001	<.001	3	5
GBM	TAMALIN →	+0.661	+1.059	.005	<.001	3	5
CCRCC	EMCN →	+1.326	+0.991	<.001	<.001	3	5
HNSC	PYGM →	+1.554	+0.735	<.001	<.001	3	5
GBM	CLDN5 →	+1.182	+1.338	<.001	<.001	3	5
GBM	GAPDHP74 →	+0.285	+0.748	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048169 vs SMTNL2 — LSCC

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