Regulation of synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic plasticity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, UTP25, and MED26_S447, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic plasticity activity versus STXBP1 in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP1 →	+0.729	+0.053	<.001	<.001	3	7
BRCA	UTP25 →	-0.334	-0.018	<.001	<.001	3	7
BRCA	MED26_S447 →	-0.381	-0.017	.007	<.001	3	6
GBM	PRPF8 →	-0.228	-0.061	<.001	.001	3	6
LSCC	UBR5 →	-0.204	-0.018	.003	.001	3	6
LSCC	URB2 →	-0.236	-0.024	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048167 vs STXBP1 — GBM

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