Regulation of synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, ARHGAP39, and MYC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic plasticity activity versus SDC4 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SDC4 →	+1.132	+0.155	.001	.005	3	6
OESOPHAGUS	ARHGAP39 →	-0.800	-0.198	.003	<.001	2	6
OESOPHAGUS	MYC →	-1.625	-0.248	.002	.003	3	5
PANCREAS	LIMA1 →	+1.148	+0.229	.006	.002	3	5
BLOOD_Myeloma	SMPD1 →	+1.830	+0.193	.001	.001	3	5
OVARY	FBRSL1 →	-1.180	-0.184	.003	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048167 vs SDC4 — LARGE_INTESTINE

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