Behavioral response to ethanol

Across TCGA patient cohorts, RNA activity of the Behavioral response to ethanol pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMD9L, RTN1, and SEMA4D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to ethanol activity versus SAMD9L in BRCA (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAMD9L →	-0.463	-0.084	<.001	.001	3	6
BRCA	RTN1 →	-0.471	-0.075	<.001	<.001	3	5
LSCC	SEMA4D →	-0.265	-0.092	.009	.009	3	5
HNSC	CASP1 →	-0.493	-0.093	.001	.002	2	6
HNSC	APOL3 →	-0.506	-0.106	.001	<.001	3	5
LSCC	PSMB10 →	-0.461	-0.099	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048149 vs SAMD9L — BRCA

Explore this scatter interactively →