Behavioral response to ethanol

Across TCGA cell cohorts, RNA activity of the Behavioral response to ethanol pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELK3, CEP162, and USP38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELK3 grouped by Behavioral response to ethanol-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELK3 →	+1.000	+0.769	.009	.005	3	5
LUNG_SCLC	CEP162 →	-0.964	-0.829	.002	.005	3	4
LUNG_NSCLC_LUSC	USP38 →	+0.897	+1.491	<.001	.001	3	4
PANCREAS	UPF3B →	-0.911	-1.282	<.001	.001	3	4
LUNG_SCLC	RAB3IL1 →	+1.481	+0.893	.002	.001	3	4
BONE	MEF2D →	+0.825	+1.882	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELK3 by Behavioral response to ethanol activity — LARGE_INTESTINE

Explore this box plot interactively →