Behavioral response to cocaine

Across TCGA patient cohorts, RNA activity of the Behavioral response to cocaine pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, ZEB2, and GIMAP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to cocaine activity versus TLN1 in UCEC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLN1 →	-0.276	-0.066	.004	<.001	3	6
OV	ZEB2 →	-0.540	-0.060	<.001	.003	3	6
BRCA	GIMAP8 →	-0.421	-0.044	<.001	<.001	3	6
LUAD	AIFM1 →	+0.255	+0.057	.001	.001	3	6
CCRCC	AIMP1 →	+0.107	+0.042	<.001	.002	3	6
GBM	SBF1 →	-0.238	-0.069	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048148 vs TLN1 — UCEC

Explore this scatter interactively →