Behavioral response to cocaine

Across TCGA cell cohorts, RNA activity of the Behavioral response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO43, CYTH3, and MAPK10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO43 grouped by Behavioral response to cocaine-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FBXO43 →	-2.302	-1.719	.006	.004	3	3
BLOOD_Lymphoma	CYTH3 →	-1.131	-1.433	.005	.008	3	3
SOFT_TISSUE	MAPK10 →	+1.156	+0.595	<.001	<.001	3	3
SOFT_TISSUE	PPP2R5E →	-0.707	-1.168	<.001	.001	3	3
LIVER	IFT52 →	-0.635	-1.458	<.001	.002	3	3
LIVER	SPATS2 →	+0.679	+1.853	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO43 by Behavioral response to cocaine activity — BLOOD_Lymphoma

Explore this box plot interactively →