Behavioral response to cocaine

Across TCGA cell cohorts, RNA activity of the Behavioral response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR2F1, WDR76, and SCO2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to cocaine activity versus NR2F1 in LUNG_NSCLC_LUAD (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NR2F1 →	+3.977	+1.693	<.001	.004	3	3
LUNG_NSCLC_LUAD	WDR76 →	+0.989	+1.704	<.001	<.001	3	3
LUNG_SCLC	SCO2 →	+0.542	+0.995	.002	.003	3	3
SKIN	CS →	+0.373	+0.810	.002	.004	3	3
OVARY	CPED1 →	+4.319	+1.801	.004	.001	3	2
LARGE_INTESTINE	ADAMTS6 →	+1.965	+2.138	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048148 vs NR2F1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →