Positive regulation of fibroblast proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM12, SYDE1, and GFPT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast proliferation activity versus ADAM12 in LUAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADAM12 →	+0.944	+0.203	<.001	<.001	3	7
BRCA	SYDE1 →	+0.537	+0.162	<.001	<.001	3	6
BRCA	GFPT2 →	+0.836	+0.206	.001	.002	3	6
BRCA	LOXL2 →	+0.797	+0.193	.002	.002	3	6
GBM	ITGA5 →	+0.867	+0.188	.001	.004	3	6
BRCA	SPATA20P1 →	+0.716	+0.188	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048146 vs ADAM12 — LUAD

Explore this scatter interactively →