Positive regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, FN1, and SLC22A4, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast proliferation activity versus FLNA in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FLNA →	+1.644	+0.155	<.001	<.001	3	14
BREAST	FN1 →	+4.319	+0.168	<.001	<.001	3	14
LUNG_NSCLC_LUSC	SLC22A4 →	+1.585	+0.194	.003	.001	3	14
PANCREAS	CSF2 →	+2.493	+0.156	<.001	<.001	3	13
SOFT_TISSUE	GPR176 →	+1.909	+0.124	<.001	<.001	3	13
SKIN	PLEC →	+1.902	+0.132	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048146 vs FLNA — LUNG_NSCLC_LUSC

Explore this scatter interactively →