Positive regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A6, GBP3, and SLBP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast proliferation activity versus S100A6 in BLOOD_Lymphoma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	S100A6 →	+5.176	+0.281	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	GBP3 →	+2.081	+0.189	<.001	.003	3	6
SKIN	SLBP →	-0.756	-0.243	.001	<.001	3	6
SKIN	FANCA →	-0.974	-0.248	.004	.007	2	7
BLOOD_Myeloma	S100A4 →	+4.966	+0.283	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	LYAR →	-0.881	-0.279	.007	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048146 vs S100A6 — BLOOD_Lymphoma

Explore this scatter interactively →