Fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB20, NUSAP1, and PIK3C2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB20 grouped by Fibroblast proliferation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZBTB20 →	-0.474	-1.551	<.001	<.001	3	4
BREAST	NUSAP1 →	+0.852	+0.794	<.001	.002	3	4
CNS	PIK3C2A →	-0.658	-1.094	<.001	.002	3	3
BONE	PNPLA8 →	-0.861	-1.607	<.001	<.001	3	3
STOMACH	DHODH →	+0.715	+1.219	<.001	<.001	3	3
BREAST	SASS6 →	+0.686	+1.002	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB20 by Fibroblast proliferation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →