Astrocyte activation

Across TCGA patient cohorts, RNA activity of the Astrocyte activation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD14, NCF1, and TNFAIP8L2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte activation activity versus CD14 in GBM (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD14 →	+0.562	+0.068	<.001	<.001	3	9
UCEC	NCF1 →	+0.878	+0.094	<.001	<.001	3	9
OV	TNFAIP8L2 →	+0.474	+0.045	<.001	.001	3	8
BRCA	WIPF1 →	+0.313	+0.041	<.001	.004	3	8
OV	C1QB →	+0.551	+0.059	.003	<.001	3	8
OV	C1R →	+0.648	+0.058	.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048143 vs CD14 — GBM

Explore this scatter interactively →