Astrocyte activation

Across TCGA cell cohorts, RNA activity of the Astrocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL5, PLCE1, and PHF5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte activation activity versus MYL5 in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYL5 →	+1.188	+1.321	<.001	<.001	3	5
BONE	PLCE1 →	-1.755	-1.469	.007	.002	3	4
SKIN	PHF5A →	-0.475	-0.650	.004	.002	3	4
SKIN	PDCD11 →	-0.684	-0.579	<.001	.007	3	4
SKIN	CWF19L1 →	-0.532	-0.818	<.001	.003	3	4
OVARY	SMIM24 →	+1.337	+1.045	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048143 vs MYL5 — PANCREAS

Explore this scatter interactively →