Somatic stem cell division

Across TCGA patient cohorts, RNA activity of the Somatic stem cell division pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH2, NAP1L3, and CD52, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic stem cell division activity versus JPH2 in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	JPH2 →	+0.335	+0.467	.001	.002	3	4
LSCC	NAP1L3 →	+0.303	+0.582	.005	<.001	3	4
PDAC	CD52 →	+0.543	+0.373	.003	.002	3	3
PDAC	RNU5A-3P →	-0.626	-0.341	<.001	.001	3	3
BRCA	WNT5B →	+0.770	+0.599	<.001	.004	3	3
BRCA	CPA4 →	+1.414	+0.546	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048103 vs JPH2 — LSCC

Explore this scatter interactively →