Autophagic cell death

Across TCGA patient cohorts, RNA activity of the Autophagic cell death pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR65, VSIG4, and DPEP2, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagic cell death activity versus GPR65 in SKCM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GPR65 →	+1.016	+0.058	<.001	<.001	3	30
CHOL	VSIG4 →	+2.189	+0.084	.001	<.001	3	30
DLBC	DPEP2 →	+1.124	+0.073	<.001	.001	3	30
SCLC	FCGR2C →	+1.103	+0.210	<.001	<.001	3	30
SCLC	TLR8 →	+1.205	+0.138	<.001	<.001	3	29
SCLC	CD37 →	+2.047	+0.197	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048102 vs GPR65 — SKCM

Explore this scatter interactively →