Autophagic cell death

Across TCGA cell cohorts, RNA activity of the Autophagic cell death pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNIH1, TRPA1, and CDK5RAP3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagic cell death activity versus CNIH1 in LUNG_SCLC (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CNIH1 →	+0.686	+1.734	.003	<.001	3	1
LUNG_SCLC	TRPA1 →	-2.903	-1.715	.001	<.001	3	1
LUNG_SCLC	CDK5RAP3 →	-1.464	-1.623	<.001	<.001	3	1
LUNG_SCLC	FOXRED1 →	-1.196	-1.734	.008	<.001	3	1
LUNG_SCLC	RAD51AP1 →	-1.170	-1.719	.003	<.001	3	1
LUNG_SCLC	COPS7A →	-0.559	-1.715	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048102 vs CNIH1 — LUNG_SCLC

Explore this scatter interactively →