Developmental pigmentation

Across TCGA patient cohorts, RNA activity of the Developmental pigmentation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, TBC1D2B, and VCL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental pigmentation activity versus RSU1 in UCEC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSU1 →	+0.644	+0.066	<.001	<.001	3	9
GBM	TBC1D2B →	+0.369	+0.047	<.001	<.001	3	9
GBM	VCL →	+0.502	+0.062	<.001	<.001	3	9
GBM	DAB2 →	+0.612	+0.040	<.001	<.001	3	9
GBM	F13A1 →	+0.851	+0.045	<.001	<.001	3	9
UCEC	ILK →	+0.616	+0.064	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048066 vs RSU1 — UCEC

Explore this scatter interactively →