Developmental pigmentation

Across TCGA patient cohorts, RNA activity of the Developmental pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTP1, BTK, and DOCK8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental pigmentation activity versus GSTP1 in LSCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GSTP1 →	-0.511	-0.215	.003	.003	3	5
LSCC	BTK →	+0.662	+0.321	<.001	.002	3	4
LSCC	DOCK8 →	+0.546	+0.294	.003	.003	3	4
LSCC	GLRX3 →	-0.362	-0.184	.006	.007	3	4
HNSC	FAM20A →	+0.572	+0.406	<.001	.005	3	4
LSCC	NDUFA8 →	-0.405	-0.218	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048066 vs GSTP1 — LSCC

Explore this scatter interactively →