Focal adhesion assembly

Across TCGA patient cohorts, RNA activity of the Focal adhesion assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS1, TNS2, and TNS2_S120, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Focal adhesion assembly activity versus TNS1 in HNSC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNS1 →	+0.630	+0.091	<.001	<.001	3	10
OV	TNS2 →	+0.421	+0.061	<.001	<.001	3	10
OV	TNS2_S120 →	+0.570	+0.050	.001	.001	3	10
GBM	GUCY1A1 →	+0.487	+0.055	<.001	<.001	3	10
UCEC	GUCY1B1 →	+0.472	+0.057	<.001	<.001	3	10
BRCA	HSPA12B →	+0.641	+0.047	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048041 vs TNS1 — HNSC

Explore this scatter interactively →