Focal adhesion assembly

Across TCGA cell cohorts, RNA activity of the Focal adhesion assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, ACTN2, and CAPNS1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Focal adhesion assembly activity versus ACTN1 in BONE (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ACTN1 →	+2.363	+0.390	<.001	<.001	3	12
BONE	ACTN2 →	+2.025	+0.449	<.001	<.001	3	12
BREAST	CAPNS1 →	+1.294	+0.307	.001	.001	3	10
KIDNEY	ITGA2 →	+1.721	+0.232	.002	.001	3	9
URINARY_TRACT	ACTN4 →	+2.368	+0.396	.003	<.001	3	8
BONE	ZYX →	+1.850	+0.461	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048041 vs ACTN1 — BONE

Explore this scatter interactively →