"Regulation of mRNA splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "Regulation of mRNA splicing, via spliceosome" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM83H_S892, EPS8L2, and GABPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mRNA splicing, via spliceosome" activity versus FAM83H_S892 in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM83H_S892 →	-0.870	-0.037	.004	.006	3	6
GBM	EPS8L2 →	-0.465	-0.022	<.001	.005	3	6
HNSC	GABPA →	+0.188	+0.056	<.001	.005	3	6
GBM	GATAD2B →	+0.300	+0.027	<.001	<.001	3	6
GBM	NCOA5 →	+0.205	+0.025	.001	.002	3	6
LUAD	ARID4B →	+0.168	+0.031	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048024 vs FAM83H_S892 — LSCC

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