"Regulation of mRNA splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "Regulation of mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNF1A-AS1, CALML4, and CAMK1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mRNA splicing, via spliceosome" activity versus HNF1A-AS1 in BRCA (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HNF1A-AS1 →	+0.066	+0.229	.002	.002	3	2
BRCA	CALML4 →	+0.247	+0.316	.002	.006	3	1
BRCA	CAMK1 →	+0.753	+0.205	.005	.007	3	1
BRCA	GLRA1 →	+0.150	+0.254	<.001	.005	3	1
BRCA	FRMPD2B →	+1.215	+0.316	<.001	.006	3	1
BRCA	PHOX2A →	+0.135	+0.283	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048024 vs HNF1A-AS1 — BRCA

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