"Regulation of mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Regulation of mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMM1, GPR180, and FSTL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMM1 grouped by "Regulation of mRNA splicing, via spliceosome"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PMM1 →	+1.107	+0.246	<.001	.001	3	5
BLOOD_Leukemia	GPR180 →	-0.744	-0.193	.001	.002	3	4
LARGE_INTESTINE	FSTL3 →	+1.559	+0.169	<.001	.005	3	4
BREAST	PCBP4 →	+1.032	+0.108	.004	.003	3	4
LUNG_NSCLC_LUAD	FIP1L1 →	-0.512	-0.149	.008	.002	3	4
SKIN	RBM3 →	+0.506	+0.161	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMM1 by "Regulation of mRNA splicing, via spliceosome" activity — BLOOD_Leukemia

Explore this box plot interactively →