"Regulation of mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Regulation of mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH2, TRA2B, and RBMX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mRNA splicing, via spliceosome" activity versus MSH2 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MSH2 →	+0.853	+0.149	.003	<.001	3	6
OVARY	TRA2B →	+0.586	+0.169	.009	<.001	3	6
BREAST	RBMX →	+0.501	+0.127	.003	.003	2	7
SKIN	SND1 →	-0.863	-0.177	<.001	.006	3	5
LUNG_SCLC	AS3MT →	+1.395	+0.100	<.001	.001	3	5
LUNG_SCLC	ACY1 →	-1.179	-0.134	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048024 vs MSH2 — BREAST

Explore this scatter interactively →