Phosphatidylinositol-mediated signaling

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELMO1, DOCK11, and CLIC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol-mediated signaling activity versus ELMO1 in GBM (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ELMO1 →	+0.687	+0.083	<.001	<.001	3	9
BRCA	DOCK11 →	+0.380	+0.040	<.001	<.001	3	8
GBM	CLIC2 →	+0.599	+0.067	<.001	<.001	3	8
GBM	IL16 →	+0.646	+0.086	<.001	<.001	3	8
HNSC	ARHGAP25 →	+0.511	+0.049	<.001	.001	3	8
LUAD	YME1L1 →	-0.300	-0.063	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048015 vs ELMO1 — GBM

Explore this scatter interactively →