Phosphatidylinositol-mediated signaling

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPH, JADE3, and SRPX2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol-mediated signaling activity versus ASPH in OVARY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASPH →	+2.091	+1.042	<.001	.002	3	10
BLOOD_Leukemia	JADE3 →	-0.839	-0.677	.001	.002	3	7
PANCREAS	SRPX2 →	+2.635	+0.354	.005	.008	3	6
PANCREAS	ILF3 →	-0.756	-0.292	.003	.009	3	6
URINARY_TRACT	SYNRG →	-0.694	-0.414	<.001	<.001	3	5
URINARY_TRACT	BAZ1B →	-0.737	-0.567	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048015 vs ASPH — OVARY

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