Hepatocyte growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Hepatocyte growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER3, CMYA5, and UBR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepatocyte growth factor receptor signaling pathway activity versus IER3 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IER3 →	+0.958	+0.146	.005	.001	3	5
HNSC	CMYA5 →	-1.194	-0.201	.002	<.001	3	4
BRCA	UBR3 →	-0.397	-0.136	.001	.002	3	4
UCEC	CALHM2 →	-0.458	-0.180	.005	<.001	3	4
PDAC	MPV17L →	-0.566	-0.244	.001	<.001	3	4
BRCA	CCPG1 →	-0.428	-0.205	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048012 vs IER3 — GBM

Explore this scatter interactively →