Hepatocyte growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Hepatocyte growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP3, SP100, and MAZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GBP3 grouped by Hepatocyte growth factor receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GBP3 →	+2.984	+1.588	<.001	<.001	3	5
SOFT_TISSUE	SP100 →	+2.848	+0.491	<.001	.007	3	5
CNS	MAZ →	-0.889	-0.645	<.001	.001	3	5
BLOOD_Lymphoma	LYSMD1 →	-1.083	-1.823	<.001	<.001	3	4
LIVER	EMC1 →	-0.939	-1.347	<.001	.003	3	4
LIVER	KLF15 →	-1.480	-1.429	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GBP3 by Hepatocyte growth factor receptor signaling pathway activity — LIVER

Explore this box plot interactively →