Hepatocyte growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Hepatocyte growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STMP1, CERS2, and IL6R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepatocyte growth factor receptor signaling pathway activity versus STMP1 in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	STMP1 →	+0.924	+0.274	.003	.002	3	5
BLOOD_Lymphoma	CERS2 →	-0.929	-0.282	<.001	.005	3	4
BLOOD_Lymphoma	IL6R →	-3.079	-0.226	.004	.007	2	5
BLOOD_Lymphoma	MME →	+4.145	+0.266	<.001	.008	3	4
BLOOD_Lymphoma	SPATA20 →	-2.290	-0.239	.006	.009	3	4
LARGE_INTESTINE	ARHGEF4 →	-1.879	-0.214	.002	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048012 vs STMP1 — SKIN

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