Platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX9, VCL_S795, and P3H3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor signaling pathway activity versus SNX9 in OV (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNX9 →	+0.354	+0.064	.001	<.001	3	10
BRCA	VCL_S795 →	+0.603	+0.039	<.001	<.001	3	10
OV	P3H3 →	+0.545	+0.046	<.001	<.001	3	10
UCEC	PRKG1 →	+0.583	+0.047	<.001	.001	3	10
BRCA	RSU1 →	+0.433	+0.051	<.001	<.001	3	9
BRCA	SERPINF1 →	+0.901	+0.049	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048008 vs SNX9 — OV

Explore this scatter interactively →