Platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, TNFAIP6, and COL5A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor signaling pathway activity versus LGALS1 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LGALS1 →	+0.713	+0.142	<.001	.001	3	5
OV	TNFAIP6 →	+1.233	+0.170	<.001	<.001	3	5
OV	COL5A1 →	+1.675	+0.176	.003	.008	3	4
OV	FCGR2A →	+1.097	+0.207	<.001	<.001	3	4
OV	SULF1 →	+1.552	+0.232	.001	<.001	3	4
OV	MMP14 →	+1.486	+0.208	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048008 vs LGALS1 — OV

Explore this scatter interactively →