Platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIK2_S509, HK3, and NCF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor signaling pathway activity versus SIK2_S509 in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIK2_S509 →	+0.996	+0.191	<.001	.001	2	4
OV	HK3 →	+0.484	+0.188	<.001	<.001	3	3
OV	NCF4 →	+0.542	+0.248	.001	<.001	3	3
OV	SNRPD2 →	-0.316	-0.198	<.001	<.001	3	3
OV	HNRNPR →	-0.435	-0.225	<.001	<.001	3	3
OV	PNN →	-0.206	-0.175	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048008 vs SIK2_S509 — GBM

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