Platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXB8, MAX, and TNIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOXB8 grouped by Platelet-derived growth factor receptor signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HOXB8 →	-0.298	-0.129	<.001	<.001	3	7
BONE	MAX →	-0.626	-0.168	<.001	.001	3	6
LIVER	TNIP1 →	-0.264	-0.084	.001	.006	3	6
LIVER	PPP1R12A →	+0.398	+0.108	.007	.003	3	5
SOFT_TISSUE	GIMAP5 →	+0.241	+0.160	<.001	.001	3	4
CNS	HLA-C →	+0.210	+0.101	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOXB8 by Platelet-derived growth factor receptor signaling pathway activity — OVARY

Explore this box plot interactively →