Platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKX, PPAT, and SLC18B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet-derived growth factor receptor signaling pathway activity versus PRKX in BONE (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PRKX →	-1.591	-0.389	.008	.003	3	5
CNS	PPAT →	-0.742	-0.265	<.001	.001	3	5
LIVER	SLC18B1 →	-2.116	-0.411	.008	.007	3	5
LARGE_INTESTINE	CCT3 →	-0.535	-0.378	<.001	.003	3	5
LIVER	ILF2 →	-0.714	-0.429	.004	.003	3	5
LIVER	HEATR3 →	-1.084	-0.446	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048008 vs PRKX — BONE

Explore this scatter interactively →