"Antigen processing and presentation, endogenous lipid antigen via MHC class Ib"

Across TCGA patient cohorts, RNA activity of the "Antigen processing and presentation, endogenous lipid antigen via MHC class Ib" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRAP2, CLIC2, and DOCK2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Antigen processing and presentation, endogenous lipid antigen via MHC class Ib" activity versus GRAP2 in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRAP2 →	+1.129	+0.787	<.001	.003	3	10
GBM	CLIC2 →	+0.646	+0.514	<.001	<.001	3	9
GBM	DOCK2 →	+0.707	+0.393	<.001	<.001	3	9
HNSC	EVL →	+0.789	+0.754	<.001	<.001	3	9
LSCC	FNBP1 →	+0.385	+0.837	<.001	<.001	3	9
GBM	GIMAP7 →	+0.659	+0.620	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048006 vs GRAP2 — GBM

Explore this scatter interactively →