Antigen processing and presentation of lipid antigen via MHC class Ib

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of lipid antigen via MHC class Ib pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DEF6, ADGRE5, and FMNL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of lipid antigen via MHC class Ib activity versus DEF6 in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DEF6 →	-0.639	-0.147	<.001	<.001	3	7
BRCA	ADGRE5 →	-0.418	-0.091	.003	.001	3	6
GBM	FMNL1 →	-0.638	-0.128	<.001	<.001	3	6
UCEC	LIMD2 →	-0.499	-0.129	<.001	.001	3	6
GBM	ACAP1 →	-0.748	-0.182	<.001	<.001	3	6
LSCC	FMNL1_S184 →	-0.936	-0.161	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048003 vs DEF6 — GBM

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