Antigen processing and presentation of lipid antigen via MHC class Ib

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of lipid antigen via MHC class Ib pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM265, TIGAR, and MCOLN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM265 grouped by Antigen processing and presentation of lipid antigen via MHC class Ib-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM265 →	+2.354	+1.413	.002	.002	3	3
SKIN	TIGAR →	-0.865	-0.936	.004	.006	3	3
SKIN	MCOLN1 →	-0.866	-1.336	.002	<.001	3	3
PANCREAS	SMARCA1 →	+2.501	+1.355	.002	<.001	2	4
BLOOD_Leukemia	PRR5L →	-2.180	-0.911	.001	.004	3	3
BLOOD_Leukemia	CDCA7L →	-2.039	-0.830	.009	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM265 by Antigen processing and presentation of lipid antigen via MHC class Ib activity — LUNG_SCLC

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